Hippocampal Subfields Group

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Activities of the Hippocampal Subfields Group - a progress update

A Marcus Wallenberg Symposium

Date: October 16 2023

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The HSG have a podcast that plan to cover various topics related to us as a group, our larger community, as well as the work that we do and how it is applied. We are eager to know more about the topics you would like to see covered on the podcast. Please give us suggestions below!

Inside the HSG: Covers updates on working group(s) activities and progress as well as information on the structure, goals, and vision of the HSG.

HSG Methods: Covers topical research spanning multiple areas of study involving the hippocampus and MTL cortices. Also delves into new methods and resources for researchers investigating these regions.

HSG Clinical: Covers clinical considerations and potential applications of the research conducted by those in the HSG community and beyond.

HSG Community: Covers updates on opportunities to connect with the HSG as well as tips about networking, conferencing, and all things academia.

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Neuroanatomy Workshop Materials (Albacete, Spain)

Resources and guidelines

Protocols and Sample Data

We provide here a single subject’s MRI dataset at reasonably high resolution to provide a common dataset on which to compare different protocols for subfield segmentation. Labeled datasets were formatted using a common scheme and served as the basis for comparison and discussion at the HSG meetings.

Please see the documentation for information about the imaging data included in the evaluation dataset, segmentation formatting requirements, and deadlines. The full dataset can be downloaded from here. You will first be asked to sign in and register for an account.

Please email Paul Yushkevich with questions regarding the quantitative component.

Acquisition recommendations

Early in our efforts we established guidelines for the type of MRI scans that are the most useful for delineating hippocampal subfields. This included recommendations on the degree to which segmentation is reasonable given a set of image data. Here we also provided basic descriptions and links to detailed descriptions of both manual and automatic segmentation protocols along with examples of lab work typifying each approach. These resources can be found on on their separate working group page here.

Publications and conference presentations

Publications and White Papers

At the August 2014 HSG meeting in Irvine CA, we put forward a vision for developing a harmonized segmentation protocol. The document below outlines the steps towards harmonization. Here is the white paper. It was followed by several collaborative publications listed below.

  1. Yushkevich, P.A., Amaral, R.S.C., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A.C., Carr, V.A., Chakravarty, M.M., Chetelat, G., Daugherty, A., Davachi, L., Ding, S.L., Ekstrom, A., Geerlings, M.I., Hassan, A., Huang, YU., Iglesias, E., La Joie, R., Kerchner, G.A., LaRoque, K., Van Leemput, K., Libby, L.A., Malykhin, N., Mueller, S.G., Olsen, R.K., Palombo, D.J., Parekh, M., Pluta, J., Preston, A.R., Pruessner, J.C., Ranganath, C., Raz, N., Schlichting, M.L., Shoemaker, D., Singh, S., Stark, C.E.L., Suthana, N., Tompary A., Turowskiah, M.M., Wagner, A.D., Wang, L., Winterburn, J.L., Wisse, L.E.M., Yassa, M.A., Zeineh, M.M. for the Hippocampal Subfield Group (HSG) (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: initial steps towards a harmonized segmentation protocol. Neuroimage 111:526-41.
  2. Wisse, L.E.M., Daugherty A., Olsen, R.K., Berron, D., Carr, V., Stark, C.E.L., Amaral, R., Amunts, K., Augustinack,J.C., Bender, A.R., Bernstein, J.D., Boccardi,M., Bocchetta, M., Burggren, A., Chakravarty, M.M., Chupin, M., Ekstrom, A., de Flores, R., Insausti,R., Kanel, P., Kedo, O., Kennedy,K., Kerchner, G.A., LaRocque, K., Liu, X., Maass, A., Malykhin, M., Mueller, S., Ofen, N., Palombo, D.J., Parekh, M., Pluta, J.B., Pruessner, J., Raz, N., Rodrigue, K., Schoemaker, D., Shafer, A.T., Steve, T., Suthana, N., Wang, L., Winterburn, J.L., Yassa, M.A., Yushkevich, P., la Joie, R., for the Hippocampal Subfield Group (HSG) (2017) A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hippocampus. 27(1)3-11.
  3. Olsen, R. K., Carr, V. A., Daugherty, A. M., la Joie, R., … Wisse, L. E. M. (2019). Progress Update from the Hippocampal Subfields Group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 439-449.
  4. Wuestefeld, A.*, Baumeister, H.*, Adams, J. N., de Flores, R., Hodgetts, C. J., Mazloum-Farzaghi, N., Olsen, R. K., Puliyadi, V., Tran, T. T., Bakker, A., Canada, K. L., Dalton, M. A., Daugherty, A. M., La Joie, R., Wang, L., Bedard, M. L., Buendia, E., Chung, E., Denning, A., … Wisse, L. E. M. (2024). Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus, 1–20.
  5. Canada, K.L.*, Mazloum-Farzaghi, N.*, G. RÃ¥dman, Adams, J.N., Bakker, A., Baumeister, H., Berron, D., Bocchetta, M., Carr, V., Dalton, M.A., de Flores, R., Keresztes, A., La Joie, R., Mueller, S.G., Raz, N., Santini, T., Shaw, T., Stark, C.E.L., Tran, T.T., Wang, L., Wisse, L.E.M., Wuestefeld, A., Yushkevich, P.A., Olsen, R.K., Daugherty, A.M. (2024) A (Sub)field Guide to Quality Control in Hippocampal Subfield Segmentation on High-resolution T2-weighted MRI. Human Brain Mapping.

Conference Presentations

We have also had several posters on this topic at international conferences:

  1. Wisse, L.E.M., Daugherty, A.M., La Joie, R., Insausti, R., Yassa, M.A., Carr, V.A., Kerchner, G.A., Mueller, S.G., Stark, C.E., Wang, L., Yushkevich, P.A., and the Hippocampal Subfields Group (2015). Towards a harmonized protocol for hippocampal subfield segmentation: an update. Alzheimer’s Association International Conference.
  2. Wisse, L.E.M., Daugherty, A.M., Amaral, R.S.C., Berron, D., Carr, V.A., Ekstrom, A., Kanel, P., Kerchner, G.A.. Mueller, S.G., Pluta, J.B., Stark, C.E., Steve, T., Wang, L., Yassa, M.A., Yushkevich, P.A., La Joie, R. on behalf of the Hippocampal Subfields Group (2016). A harmonized protocol for medial temporal lobe subfield segmentation: initial results of the 3-tesla protocol for the hippocampal body. Alzheimer’s Association International Conference.
  3. Wisse, L., Daugherty, A.M., Olsen, R.K., Amaral, R.S.C., Berron, D., Carr, V.A., Ekstrom, A., Kanel, P., Kerchner, G.A., Mueller, S.G., Pluta, J.B., Stark, C.E., Steve, T.A., Wang, L., Yassa, M.A., Yushkevich, P., La Joie, R. (2016). A harmonized protocol for In vivo human medial temporal lobe subfield segmentation: initial results of the 3 tesla protocol for the hippocampal body. Society for Neuroscience Nanosymposium.
  4. Olsen, R., Daugherty, A., La Joie, R., Wisse, L., Amaral, R., Berron, D., de Flores, R., Ekstrom, E., Kanel, P., Malykhin, N., Mueller, S., Pluta, J., Stark, C., Steve, T., Wang, L., Yassa, M.A., Yushkevich, P., Carr, V., and the Hippocampal Subfields Group (2018). A harmonized protocol for in vivo human hippocampal subfield segmentation: initial results of the 3 tesla protocol. International Conference on Learning and Memory.
  5. La Joie, R., Daugherty, A., Wisse, L., Amaral, R., Amunts, K., Augustinack, J., Bakker, A., Bender, A., Berron, D., Burggren, A., Chakravarty, M., de Flores, R., Ding, S.L., Ekstrom, A., Kanel, P., Kedo, O., Insausti, R., Malykhin, N., Mueller, S., Ofen, N., Polombo, D., Pluta, J., Schoemaker, D., Stark, C., Steve, T., Wang, L., Yassa, M., Yu, Q., Yushkevich, P., Carr V., Olsen, R., on behalf of the Hippocampal Subfields Group (2018). A harmonized protocol for in vivo human hippocampal subfield segmentation: initial results of the 3 Tesla protocol. Alzheimer’s Association International Conference.
  6. Carr, V. A., La Joie, R., Olsen, R. K., Wisse, L. E. M., Amunts, M. C., Augustinack, J. C., Bakker, A., Bender, A. R., Berron, D., Ding, S. L., Burggren, A. C., De Flores, R., Chakravarty, M., Ekstrom, A. D., Kanel, P., Kedo, O., Insausti, R., Malykhin, N. V., Mueller, S. G., Ofen, N., Pluta, J. B., Palombo, D. J., Schoemaker, D., Stark, C. E. L., Steve, T., Wang, L., Yassa, M. A., Yu, Q., Yushkevich, P. A., Daugherty, A. M., on behalf of the Hippocampal Subfields Group (2018). Preliminary results of the Hippocampal Subfields Group harmonized protocol for segmenting human hippocampal subfields on 3T MRI. Annual meeting of the Society for Neuroscience.
  7. La Joie, R., Daugherty, A., Wisse, L., Amaral, R., Amunts, K., Augustinack, J., Bakker, A., …, Carr V., & Olsen, R. (2018). A harmonized protocol for in vivo human hippocampal subfield segmentation: initial results of the 3 Tesla protocol. Alzheimer’s Association International Conference, Chicago.
  8. Wisse, L. E. M., Berron, D., Olsen, R. K., Daughterty, A., … Carr, V. A., & La Joie, R. (2019). The development of a valid, reliable, harmonized segmentation protocol for medial temporal lobe subregions: A progress update. Alzheimer’s Association International Conference, Los Angeles.
  9. La Joie, R., Olsen, R. K., Berron, D., Amunts, K., Augustinack, J., Bakker, A., … Carr, V. A., Wisse, L. E. M., & Daugherty, A. (2020) The development of a valid, reliable, harmonized segmentation protocol for hippocampal subfields and medial temporal lobe cortices: A progress update. Alzheimer’s Association International Conference, Virtual.
  10. Wisse, L. E. M., La Joie, R., Olsen, R. K., Berron, D., Amunts, K., Augustinack, J., … Carr, V. A., & Daugherty, A. (2021). The development of a valid, reliable, harmonized segmentation protocol for medial temporal lobe subregions: A progress update. International Conference on Alzheimer’s and Parkinson’s Diseases, Virtual.
  11. Carr, V. A., Berron, D., Daugherty, A. M., La Joie, R., Wisse, L. E. M., …, & Olsen, R. K. (2021). Hippocampal Subfields Group progress update: The development of a valid, reliable, harmonized segmentation protocol for medial temporal lobe subregions. Society for Neuroscience, Virtual.
  12. Olsen, RK, Augustinack, JC, Ding, SL, Insausti, R, Kedo, O, Amunts, KM, Adams, JN, Bakker, A, Baumeister, H, Daugherty, AM, De Flores, R, Hodgetts, CJ, La Joie, R, Mazloum-Farzaghi, N, Puliyad, V, Stark, CE, Tran, TT, Wang, L, Wuestefeld, A, Yushkevich, P, Wisse, L, Berron, D. (2022) Histological delineation of the entorhinal, perirhinal and parahippocampal cortices for the development of a harmonized segmentation protocol for 3T MRI. Society for Neuroscience, San Diego.
  13. Daugherty, AM, Saifullah, S, Amunts, K, Bakker, A, Berron, D, Brown, T, Burggren, A, Chetelat, G, De Flores, R, Ding, SL, Insausti, R, Kedo, O, La Joie, R, Malykhin, N, Martinez, A, Mueller, S, Olsen, R, Palombo, D, Raz, N, Stark, C, Wang, L, Wisse, L, Yushkevich, P, Carr, V. (2022) Hippocampal subfields group progress update: consensus protocol to segment subfields within the hippocampal body on high-resolution in vivo MRI. Society for Neuroscience, San Diego.
  14. Adams JN, Baumeister H, Doan T, Maass A, Mazloum-Farzaghi N, Tran TT, Wuestefeld A, Augustinack JC, Ding SL, Insausti R, Kedo O, Bakker A, Berron D, Canada KL, Carr VA, Dalton MA, Daugherty AM, de Flores R, La Joie R, Mueller SG, Olsen RK, Stark CEL, Wang L, Wisse LEM, Yushkevich P (2024).A harmonized, histology-based protocol for selection of medial temporal lobe cortical subregion ranges on magnetic resonance imaging. Alzheimer’s Association International Conference.
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