Resources – Hippocampal Subfields Group (beta site)

Material from previous events

Publications and conference talks

Check out video resources such as tutorials, our podcast, and more on our YouTube channel

Check out resources publicly available from previous meetings.

Check out our publicly material and recommendations.

Check out our current publications and conference presentations.

HSG YouTube

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Inside the HSG
HSG Methods
HSG Clinical
HSG Community

Inside the HSG: Covers updates on working group(s) activities and progress as well as information on the structure, goals, and vision of the HSG.

HSG Methods: Covers topical research spanning multiple areas of study involving the hippocampus and MTL cortices. Also delves into new methods and resources for researchers investigating these regions.

HSG Clinical: Covers clinical considerations and potential applications of the research conducted by those in the HSG community and beyond.

HSG Community: Covers updates on opportunities to connect with the HSG as well as tips about networking, conferencing, and all things academia.

Material from previous events

Neuroanatomy Workshop Materials (Albacete, Spain)

Recordings and slides from the meeting at the University of Castilla-La Mancha, Albacete, Spain in June 2023 will be shared here shortly.

Resources and recommendations

Protocols and Sample Data

We provide here a single subject’s MRI dataset at reasonably high resolution to provide a common dataset on which to compare different protocols for subfield segmentation. Labeled datasets were formatted using a common scheme and served as the basis for comparison and discussion at the HSG meetings.

Please see the documentation for information about the imaging data included in the evaluation dataset, segmentation formatting requirements, and deadlines. The full dataset can be downloaded from here. You will first be asked to sign in and register for an account.

Please email Paul Yushkevich with questions regarding the quantitative component.

Publications and conference presentations

Publications and White Papers

At the August 2014 HSG meeting in Irvine CA, we put forward a vision for developing a harmonized segmentation protocol. The document below outlines the steps towards harmonization. Here is the white paper. It has been followed by several collaborative publications listed below.

Yushkevich, P.A., Amaral, R.S.C., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A.C., Carr, V.A., Chakravarty, M.M., Chetelat, G., Daugherty, A., Davachi, L., Ding, S.L., Ekstrom, A., Geerlings, M.I., Hassan, A., Huang, YU., Iglesias, E., La Joie, R., Kerchner, G.A., LaRoque, K., Van Leemput, K., Libby, L.A., Malykhin, N., Mueller, S.G., Olsen, R.K., Palombo, D.J., Parekh, M., Pluta, J., Preston, A.R., Pruessner, J.C., Ranganath, C., Raz, N., Schlichting, M.L., Shoemaker, D., Singh, S., Stark, C.E.L., Suthana, N., Tompary A., Turowskiah, M.M., Wagner, A.D., Wang, L., Winterburn, J.L., Wisse, L.E.M., Yassa, M.A., Zeineh, M.M. for the Hippocampal Subfield Group (HSG) (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: initial steps towards a harmonized segmentation protocol. Neuroimage 111:526-41.
Wisse, L.E.M., Daugherty A., Olsen, R.K., Berron, D., Carr, V., Stark, C.E.L., Amaral, R., Amunts, K., Augustinack,J.C., Bender, A.R., Bernstein, J.D., Boccardi,M., Bocchetta, M., Burggren, A., Chakravarty, M.M., Chupin, M., Ekstrom, A., de Flores, R., Insausti,R., Kanel, P., Kedo, O., Kennedy,K., Kerchner, G.A., LaRocque, K., Liu, X., Maass, A., Malykhin, M., Mueller, S., Ofen, N., Palombo, D.J., Parekh, M., Pluta, J.B., Pruessner, J., Raz, N., Rodrigue, K., Schoemaker, D., Shafer, A.T., Steve, T., Suthana, N., Wang, L., Winterburn, J.L., Yassa, M.A., Yushkevich, P., la Joie, R., for the Hippocampal Subfield Group (HSG) (2017) A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hippocampus. 27(1)3-11.
Olsen, R. K., Carr, V. A., Daugherty, A. M., la Joie, R., … Wisse, L. E. M. (2019). Progress Update from the Hippocampal Subfields Group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 439-449.

Conference Presentations

We have also had several posters on this topic at international conferences:

Wisse, L.E.M., Daugherty, A.M., La Joie, R., Insausti, R., Yassa, M.A., Carr, V.A., Kerchner, G.A., Mueller, S.G., Stark, C.E., Wang, L., Yushkevich, P.A., and the Hippocampal Subfields Group (2015). Towards a harmonized protocol for hippocampal subfield segmentation: an update. Alzheimer’s Association International Conference.
Wisse, L.E.M., Daugherty, A.M., Amaral, R.S.C., Berron, D., Carr, V.A., Ekstrom, A., Kanel, P., Kerchner, G.A.. Mueller, S.G., Pluta, J.B., Stark, C.E., Steve, T., Wang, L., Yassa, M.A., Yushkevich, P.A., La Joie, R. on behalf of the Hippocampal Subfields Group (2016). A harmonized protocol for medial temporal lobe subfield segmentation: initial results of the 3-tesla protocol for the hippocampal body. Alzheimer’s Association International Conference.
Wisse, L., Daugherty, A.M., Olsen, R.K., Amaral, R.S.C., Berron, D., Carr, V.A., Ekstrom, A., Kanel, P., Kerchner, G.A., Mueller, S.G., Pluta, J.B., Stark, C.E., Steve, T.A., Wang, L., Yassa, M.A., Yushkevich, P., La Joie, R. (2016). A harmonized protocol for In vivo human medial temporal lobe subfield segmentation: initial results of the 3 tesla protocol for the hippocampal body. Society for Neuroscience Nanosymposium.
Olsen, R., Daugherty, A., La Joie, R., Wisse, L., Amaral, R., Berron, D., de Flores, R., Ekstrom, E., Kanel, P., Malykhin, N., Mueller, S., Pluta, J., Stark, C., Steve, T., Wang, L., Yassa, M.A., Yushkevich, P., Carr, V., and the Hippocampal Subfields Group (2018). A harmonized protocol for in vivo human hippocampal subfield segmentation: initial results of the 3 tesla protocol. International Conference on Learning and Memory.
La Joie, R., Daugherty, A., Wisse, L., Amaral, R., Amunts, K., Augustinack, J., Bakker, A., Bender, A., Berron, D., Burggren, A., Chakravarty, M., de Flores, R., Ding, S.L., Ekstrom, A., Kanel, P., Kedo, O., Insausti, R., Malykhin, N., Mueller, S., Ofen, N., Polombo, D., Pluta, J., Schoemaker, D., Stark, C., Steve, T., Wang, L., Yassa, M., Yu, Q., Yushkevich, P., Carr V., Olsen, R., on behalf of the Hippocampal Subfields Group (2018). A harmonized protocol for in vivo human hippocampal subfield segmentation: initial results of the 3 Tesla protocol. Alzheimer’s Association International Conference.
Carr, V. A., La Joie, R., Olsen, R. K., Wisse, L. E. M., Amunts, M. C., Augustinack, J. C., Bakker, A., Bender, A. R., Berron, D., Ding, S. L., Burggren, A. C., De Flores, R., Chakravarty, M., Ekstrom, A. D., Kanel, P., Kedo, O., Insausti, R., Malykhin, N. V., Mueller, S. G., Ofen, N., Pluta, J. B., Palombo, D. J., Schoemaker, D., Stark, C. E. L., Steve, T., Wang, L., Yassa, M. A., Yu, Q., Yushkevich, P. A., Daugherty, A. M., on behalf of the Hippocampal Subfields Group (2018). Preliminary results of the Hippocampal Subfields Group harmonized protocol for segmenting human hippocampal subfields on 3T MRI. Annual meeting of the Society for Neuroscience.